ORM2 in Type 2 Diabetes and Coronary Artery Disease: a potential link between insulin resistance and vascular inflammation

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ORM2, a liver-derived acute-phase glycoprotein, may connect metabolic dysfunction and vascular inflammation in T2DM and CAD. Experimental and associative clinical data link reduced ORM2 to insulin resistance and hepatic steatosis, and recombinant ORM2 reduces atherosclerosis and steatohepatitis in preclinical models, but prospective clinical and genetic studies are needed to establish causality and therapeutic potential.

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